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|
Description
|
Gene marker
|
CDK1
|
HMMR
|
PTTG1
|
TTK
|
|---|
|
Cor
|
P
|
Cor
|
P
|
Cor
|
P
|
Cor
|
P
|
|---|
|
CD8+ T cell
|
CD8A
|
0.198
|
***
|
0.139
|
**
|
0.164
|
**
|
0.188
|
***
|
|
CD8B
|
0.184
|
***
|
0.096
|
0.064
|
0.226
|
***
|
0.165
|
**
|
|
T cell (general)
|
CD3D
|
0.274
|
***
|
0.154
|
**
|
0.333
|
***
|
0.266
|
***
|
|
CD3E
|
0.202
|
***
|
0.120
|
*
|
0.175
|
***
|
0.195
|
***
|
|
CD2
|
0.216
|
***
|
0.121
|
*
|
0.204
|
***
|
0.204
|
***
|
|
B cell
|
CD19
|
0.273
|
***
|
0.204
|
***
|
0.247
|
***
|
0.273
|
***
|
|
CD79A
|
0.158
|
**
|
0.065
|
0.212
|
0.116
|
*
|
0.177
|
***
|
|
Monocyte
|
CD86
|
0.284
|
***
|
0.266
|
***
|
0.250
|
***
|
0.283
|
***
|
|
CD115
|
0.131
|
*
|
0.138
|
**
|
0.102
|
*
|
0.119
|
*
|
|
TAM
|
CCL2
|
0.039
|
0.459
|
0.023
|
0.656
|
− 0.023
|
0.665
|
0.021
|
0.682
|
|
CD68
|
0.230
|
***
|
0.186
|
***
|
0.149
|
*
|
0.204
|
***
|
|
IL10
|
0.219
|
***
|
0.223
|
***
|
0.156
|
*
|
0.235
|
***
|
|
M1 macrophage
|
NOS2
|
− 0.020
|
0.695
|
0.080
|
0.123
|
− 0.140
|
**
|
− 0.005
|
0.926
|
|
IRF5
|
0.394
|
***
|
0.407
|
***
|
0.291
|
***
|
0.373
|
***
|
|
COX2
|
0.101
|
0.053
|
0.071
|
0.171
|
− 0.025
|
0.637
|
0.094
|
0.070
|
|
M2 Macrophage
|
CD163
|
0.067
|
0.197
|
0.153
|
**
|
− 0.022
|
0.676
|
0.073
|
0.160
|
|
VSIG4
|
0.080
|
0.123
|
0.138
|
**
|
0.024
|
0.647
|
0.059
|
0.255
|
|
MS4A4A
|
0.089
|
0.086
|
0.142
|
**
|
0.027
|
0.601
|
0.079
|
0.128
|
|
Neutrophils
|
CD66b
|
0.123
|
*
|
0.096
|
0.066
|
0.094
|
0.071
|
0.107
|
*
|
|
CD11b
|
0.257
|
***
|
0.333
|
***
|
0.237
|
***
|
0.280
|
***
|
|
CCR7
|
0.089
|
0.086
|
0.045
|
0.385
|
− 0.030
|
0.569
|
0.070
|
0.181
|
|
Natural killer cell
|
KIR3DL1
|
0.010
|
0.843
|
0.068
|
0.189
|
− 0.053
|
0.308
|
0.009
|
0.869
|
|
KIR2DL1
|
− 0.035
|
0.500
|
− 0.023
|
0.656
|
− 0.068
|
0.190
|
− 0.044
|
0.393
|
|
KIR2DS4
|
0.075
|
0.148
|
0.076
|
0.142
|
0.029
|
0.581
|
0.044
|
0.400
|
|
Dendritic cell
|
CD11C
|
0.331
|
***
|
0.310
|
***
|
0.246
|
***
|
0.326
|
***
|
|
CD1C
|
0.121
|
*
|
0.066
|
0.204
|
0.041
|
0.434
|
0.104
|
*
|
|
NRP1
|
0.231
|
***
|
0.195
|
***
|
0.005
|
0.916
|
0.180
|
***
|
|
PDL1
|
CD274
|
0.209
|
***
|
0.334
|
***
|
0.062
|
0.230
|
0.062
|
0.230
|
|
Th l
|
STAT4
|
0.262
|
***
|
0.179
|
***
|
0.215
|
***
|
0.246
|
***
|
|
STAT1
|
0.372
|
***
|
0.372
|
***
|
0.248
|
***
|
0.398
|
***
|
|
TBX21
|
0.081
|
0.119
|
0.050
|
0.341
|
0.018
|
0.736
|
0.084
|
0.107
|
|
CD4
|
0.222
|
***
|
0.232
|
***
|
0.123
|
*
|
0.228
|
***
|
|
IFNG
|
0.266
|
***
|
0.219
|
***
|
0.285
|
***
|
0.275
|
***
|
|
Th 2
|
GATA3
|
0.203
|
***
|
0.135
|
**
|
0.133
|
*
|
0.185
|
***
|
|
STAT6
|
0.114
|
*
|
0.192
|
***
|
− 0.108
|
*
|
0.115
|
*
|
|
CXCR4
|
0.315
|
***
|
0.224
|
***
|
0.204
|
***
|
0.292
|
***
|
|
CCR4
|
0.206
|
***
|
0.220
|
***
|
− 0.023
|
0.663
|
0.213
|
***
|
|
Treg
|
FOXP3
|
0.163
|
**
|
0.271
|
***
|
0.023
|
0.655
|
0.205
|
***
|
|
CCR8
|
0.392
|
***
|
0.418
|
***
|
0.209
|
***
|
0.403
|
***
|
|
STAT5B
|
0.247
|
***
|
0.355
|
***
|
− 0.022
|
0.676
|
0.278
|
***
|
|
TGFB1
|
0.278
|
***
|
0.174
|
***
|
0.207
|
***
|
0.253
|
***
|
|
T cell exhaustion
|
PD-1
|
0.330
|
***
|
0.196
|
***
|
0.333
|
***
|
0.308
|
***
|
|
CTLA4
|
0.357
|
***
|
0.244
|
***
|
0.384
|
***
|
0.348
|
***
|
|
LAG3
|
0.294
|
***
|
0.205
|
***
|
0.348
|
***
|
0.318
|
***
|
|
TIM-3
|
0.296
|
***
|
0.281
|
***
|
0.272
|
***
|
0.289
|
***
|
|
GZMB
|
0.092
|
0.078
|
0.048
|
0.355
|
0.123
|
*
|
0.065
|
0.212
|
- *P < 0.05; **P < 0.01; ***P < 0.0001