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Table 3 Association of genetic ancestry (categorical variable)a with CRC status by age at recruitment

From: Association of genetic ancestry with colorectal tumor location in Puerto Rican Latinos

Ancestry OR< 60 years OR≥ 60 years
  ORunadjusted ORadjustedb ORadjustedc ORunadjusted ORadjustedb ORadjustedc
European ancestry
  ≤ (0.63) 1.0    1.0   
  > (0.63) 0.91 (0.63–1.31) 0.85 (0.49–1.48) 0.94 (0.53–1.67) 0.95 (0.62–1.47) 0.95 (0.51–1.78) 0.97 (0.51–1.86)
African ancestry
  ≤ (0.18) 1.0    1.0   
  > (0.18) 1.14 (0.79–1.63) 1.11 (0.64–1.92) 1.07 (0.60–1.91) 1.18 (0.76–1.83) 1.25 (0.67–2.35) 1.32 (0.70–2.52)
Amerindian ancestry
  ≤ (0.17) 1.0    1.0   
  > (0.17) 1.35 (0.94–1.94) 1.39 (0.79–2.43) 1.31 (0.73–2.34) 1.00 (0.65–1.55) 0.76 (0.41–1.40) 0.75 (0.40–1.40)
  1. aDichotomous variables were analyzed using the median value of each ancestry marker among controls as a cut-off
  2. bPOR’s adjusted by age at recruitment, gender, education, and family history of CRC
  3. cPOR’s adjusted by age at recruitment, gender, education, and family history of CRC, ever smoked, and current drinking
  4. dCategorical variables were categorized into quartiles and treated as continuous variables to measure the variation in risk per 25% increase of each ancestry marker
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Human Genomics

ISSN: 1479-7364