The X chromosome and sex-specific effects in infectious disease susceptibility

Table 2 TLR8 association studies from different populations

Study	Cohort	Case	Control	SNP	Allele	Gender	OR*	95% CI*	P value
Davila et al. [98]	Indonesia	77	49	rs3764879	C	Male	1.9	1.2–2.7	0.012
		76	74	rs3764879	C	Female	1.1	0.8–1.7	0.44
		76	51	rs3761624	A	Male	1.8	1.2–2.8	0.007
		76	74	rs3761624	A	Female	1.1	0.8–1.7	0.44
		76	50	rs3788935	A	Male	1.8	1.2–2.7	0.017
		76	74	rs3788935	A	Female	1.1	0.8–1.7	0.44
		76	51	rs3764880	A	Male	1.8	1.2–2.9	0.007
		76	74	rs3764880	A	Female	1.1	0.8–1.7	0.44
	Russia	1067	994	rs3764879	C	Male	1.2	1.02–1.48	0.03
		1069	997	rs3788935	A	Male	1.2	1.02–1.48	0.03
		1070	1000	rs3761624	A	Male	1.2	1.01–1.46	0.04
		1069	997	rs3764880	A	Male	1.2	1.02–1.48	0.03
Dalgic et al. [99]	Turkish children	72	62	rs3764880	A	Male	0.43	0.16–0.72	0.007
		156	124	rs3764880	A	Female	NS	NS	NS
		72	62	rs3764879	C	Male	NS	NS	NS
		156	124	rs3764879	C	Female	NS	NS	NS
Hashemi-Shahri et al. [100]	Iran	77	62	rs3764880	G	Male	1.15	0.84–1.59	0.80
Hashemi-Shahri et al. [100]	Iran	196	166	rs3764880	G	Female	1.15	0.75–1.75	0.51
Bukhari et al. [101]	Pakistan	45	22	rs3764880	A	Male	/	/	< 0.0001
Bukhari et al. [101]	Pakistan	58	65	rs3764880	A	Female	0.363	0.199–0.660	0.0013
Salie et al. [97]	SAC	204	99	rs3761624	A	Male	/	/	0.164
		217	336	rs3761624	A	Female	1.54	1.19–1.99	< 0.001
		205	99	rs3764879	C	Male	0.72	0.55–0.93	0.013
		220	334	rs3764879	C	Female	1.41	1.08–1.83	0.011
		1887	81	rs3764880	A	Male	0.75	0.57–0.98	0.036
		199	306	rs3764880	A	Female	1.42	1.09–1.87	0.011
Lai et al. [102]	Chinese	96	146	rs3764879	C	Male	4.04	1.82–8.99	< 0.001
Lai et al. [102]	Chinese	40	97	rs3764879	C	Female	5.05	0.44–57.38	0.191

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